CTT Research Leader

Dr. Karthikeyan Mythreye

Karthikeyan

Assistant Professor
Department of  Chemistry & Biochemistry,
College of Arts and Sciences, USC
 

Project:
Targeting inhibin in cancers lacking the type III TGF-beta receptor 

Goal: Validate and explore inhibin as a novel potential cancer target for antibody-based and small-molecule drugs.


Mentors

    Kiaris
          Igor Roninson                     Hippokratis Kiaris

Dr. Peisheng Xu

Xu

Assistant Professor
Department of Drug Discovery and Biomedical Sciences,
SC College of Pharmacy.
College of Arts and Sciences, USC

Project:
Dual responsive nanoparticle for brain targeted drug delivery

Goal: Develop a highly selective and efficient system for drug delivery into the brain and test this system in a model of Alzheimer’s disease.


Mentors

Qian Wang    
           Qian Wang                               Mark Kindy

Michael Shtutman

Shtutman

Assistant Professor
Department of Drug Discovery and Biomedical Sciences,
SC College of Pharmacy.
College of Arts and Sciences, USC

Project:
Targeting COPZ1 in miR-152 deficient tumor cells
 

Goal: Develop an anti-cancer drug that kills both dividing and non-dividing tumor cells, while sparing normal tissues, by targeting coatomer protein complex.


Mentors

    Kiaris
        Igor Roninson                            Kim Creek

Eugenia Broude

Eugenia Broude

Assistant Professor
Department of Drug Discovery and Biomedical Sciences,
SC College of Pharmacy.
College of Arts and Sciences, USC

Project:
Potentiating targeted drugs in breast cancer via transcription-regulating kinases
 

Goal: Develop new approaches to improving the efficacy of breast cancer therapy by combining targeted drugs with novel transcription-regulating kinase inhibitors.


Mentors

    https://www.sccp.sc.edu/Phillip_Buckhaults
       Hippokratis Kiaris                  Phillip Buckhaults

Former Research Project Leaders

Michy Kelly

Michy Kelly
Project:

Selective Targeting of Phosphodiesterase 11A Transcription and Catalytic Activity

Goal: Identify the molecular mechanisms that control Phosphodiesterase 11A (PDE11A) transcription and/or catalytic activity in order to reveal new opportunities for developing PDE11A-targeted therapeutics.


Mentors

Qian Wang 
      Igor Roninson       

Jim Fidal
          Jim Fadel

Norma Frizzell

Norma Frizzell
Project:

Targeting Fumarate and Protein Succination for Mitochondrial Disease Treatment

Goal: Validate and explore a new metabolic target for genetic neuropathological diseases associated with aberrant mitochondrial function.
 


Mentors

Rick Schnellmann 
   Rick Schnellmann     

Lawrence Reagan
   Lawrence Reagan